Underlying Pathophysiology

Metabolic acidosis damages kidney, bone, and muscle4,6,18,19

There are multiple serious consequences of chronic metabolic acidosis4,6,18-20

Image depicting serious consequences of chronic metabolic acidosis Image depicting serious consequences of chronic metabolic acidosis

The pathophysiology of metabolic acidosis is associated with loss of bone mineral density1,20,21

Metabolic acidosis contributes to muscle wasting in CKD as a result of increased muscle catabolism1,20

Metabolic acidosis is both a complication of CKD as well as an underlying cause of CKD progression1,4,10,17,20

Image depicting decreased Acid Secretion by the Kidneys in CKD Patients

Hear from a Nephrologist

David A Bushinsky, MD*:
What is the relationship between metabolic acidosis and CKD progression?

*Dr Bushinsky is a paid consultant of TRICIDA, Inc.

Continue to the next page to learn more about how metabolic acidosis can impair physical function

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Kraut JA and Madias NE (2017):
Adverse effects of the metabolic acidosis of chronic kidney disease
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