Underlying Pathophysiology

Metabolic acidosis damages kidney, bone, and muscle4,6,20,34,35

There are multiple serious consequences of chronic metabolic acidosis4,6,20,34,35

Image depicting serious consequences of chronic metabolic acidosis Image depicting serious consequences of chronic metabolic acidosis

Metabolic acidosis is both a complication of CKD as well as an underlying cause of CKD progression1,4,10,17,20

Image depicting certain effects of decreased acid secretion by the kidneys in CKD patients

Hear from a Nephrologist

Donald Wesson, MD, MBA*:
How does metabolic acidosis cause chronic kidney disease progression?

*Dr Wesson is a paid consultant of TRICIDA, Inc.

Download Dr Wesson's presentation featured in this video

The pathophysiology of metabolic acidosis is associated with loss of bone mineral density1,20,36

Acid buffering by bone with increased acid retention.

Metabolic acidosis contributes to muscle wasting in CKD as a result of increased muscle catabolism1,20

Hear from a Nephrologist

David A Bushinsky, MD:
How does metabolic acidosis impair muscle and bone health?

†Dr Bushinsky is a paid consultant of TRICIDA, Inc.

Download Dr Bushinsky's presentation featured in this video

Continue to the next page to learn more about how metabolic acidosis can impair physical function

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Kraut JA and Madias NE (2017):
Adverse effects of the metabolic acidosis of chronic kidney disease
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