INDEPENDENT RISK FACTOR FOR CKD PROGRESSION

Metabolic acidosis is both a complication of CKD and a cause of its progression1,4,10,17,20

Increasing serum bicarbonate has been shown to slow CKD progression21-24

Metabolic acidosis is associated with an increased risk of CKD progression and risk of mortality19,28-32


Metabolic acidosis was shown to be an independent predictor of adverse renal outcomes33

INCIDENCE RATE OF DD40 AT 2 YEARS33

Bar graph showing the incidence of DD40 at 2 years for people with metabolic acidosis vs people with normal serum bicarbonate levels
Each 1 mEq/L increase in serum bicarbonate leads to a 13% decrease in DD40

After controlling for potential confounders.

Download the Reaven et al Poster #FR-PO274, ASN, 2019 for more information about these data

KDIGO guidelines recommend using validated risk prediction tools to evaluate patient risk of progression to kidney failure6

Hear from a Nephrologist

Navdeep Tangri, MD, PhD:
What is the role of metabolic acidosis in CKD risk prediction?

‡Dr Tangri is a paid consultant of TRICIDA, Inc.

Continue to the next page to learn more about the underlying pathophysiology and consequences of metabolic acidosis

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Read more

Wesson DE et al (2020):
Mechanisms of metabolic acidosis–induced kidney injury in chronic kidney disease
Go to ARTICLE
Reaven et al Poster #FR-PO274, ASN, 2019:
Metabolic acidosis is an independent predictor of adverse renal outcomes and higher costs in patients with chronic kidney disease
download poster
Goraya N and Wesson DE (2019):
Clinical evidence that treatment of metabolic acidosis slows the progression of chronic kidney disease
Go to ARTICLE
Bushinsky DA (2019):
Tolerance to sodium in patients with CKD-induced metabolic acidosis: does the accompanying anion matter?
Go to ARTICLE