Serum bicarbonate levels determine severity of acidosis
*Data on file. NHANES 1999-2004 reports prevalence of CKD Stages 3 and 4 for the US adult population ages 20 and older. CKD Stage 3 and 4 prevalence was calculated using NHANES prevalence and 2016 US Census data. Stage 3a (70%) and 3b (30%) were approximated using NCCD-CDC Surveillance System; Stage 5 non-dialysis included based on Inker et al grouping of Stage 4 & 5 prevalence rate. Metabolic acidosis prevalence by Stage 3a, 3b, 4, and 5 reported by Inker et al (2011).